Chasing the Infecting HIV-1
نویسندگان
چکیده
منابع مشابه
Chasing the infecting HIV-1.
In the absence of an effective prophylactic vaccine and successful viral eradication strategies, the burden of human immunodeficiency virus type 1 (HIV-1) infection and disease continues to grow worldwide. The events characterizing primary HIV-1 infection and the early stages of the infection have been the focus of extensive research addressing the modalities of HIV-1 transmission. A thorough u...
متن کاملHIV-1 transmission biology: selection and characteristics of infecting viruses.
Individuals with recent human immunodeficiency virus type 1 (HIV-1) acquisition are likely to be a major source for other new infections because they have a high level of plasma virus, and the circulating virions possess unique properties that are highly suited for transmission. The acute infection period, however, presents a unique "window of opportunity," because there are a limited number of...
متن کاملDisease progression by infecting HIV-1 subtype in a seroconverter cohort in sub-Saharan Africa
OBJECTIVE To describe immunologic, virologic, and clinical HIV disease progression by HIV-1 subtype among Africans with well documented estimated dates of HIV infection (EDIs). DESIGN Prospective cohort. METHODS Adults and youth with documented HIV-1 infection in the past 12 months were recruited from seroincidence cohorts in East and Southern Africa and followed at 3-6 month intervals. Blo...
متن کاملInfecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa
INTRODUCTION Long-term natural history cohorts of HIV-1 in the absence of treatment provide the best measure of virulence by different viral subtypes. METHODS Newly HIV infected Ugandan and Zimbabwean women (N=303) were recruited and monitored for clinical, social, behavioral, immunological and viral parameters for 3 to 9.5years. RESULTS Ugandan and Zimbabwean women infected with HIV-1 subt...
متن کاملDeletion, insertion and stop codon mutations in vif genes of HIV-1 infecting slow progressor patients.
BACKGROUND Variable progression towards AIDS has been described and has been related to viral and host factors. Around 10% of the HIV-1 infected patients are slow progressors (SP), not presenting with AIDS disease signs even after more than 10 years of infection. Viral gene defects have been associated with the disease progression but more studies are still needed. METHODOLOGY The sequence of...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2011
ISSN: 1537-6591,1058-4838
DOI: 10.1093/cid/cir737